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If you ask a teenager about 'Special K' these days, don’t expect them to immediately reach for a cereal bowl. That's because it's the nickname of the drug du jour — ketamine.
Although immensely popular with younger people, few parents are savvy about the new recreational drug that's giving teenagers a quick, dramatic high.
Ketamine is used by veterinarians, doctors and dentists as a dissociative anaesthetic and painkiller, but is appearing increasingly on the streets.
"Kids are taking it at clubs, but it's also a date rape drug," Det. Sgt. Howie Page of Toronto police explains. "GHB, the most popular date rape drug, renders the victim unconscious — they don't remember anything. Ketamine puts them in a semi-conscious state, paralyzing them so they can't fight back. Young women who willingly take it are putting themselves in danger."
Wende Wood, a psychiatric pharmacist with the Centre for Addiction and Mental Health, adds, "Parents should be concerned that if their child takes ketamine, they may be putting themselves in a situation where could be raped or harmed. I'd worry also if they were really drawn to it. Why do they need to escape?"
Ketamine is also showing up mixed with other drugs, such as ecstasy.
Teenagers have a variety of reasons for using it.
It's cheap — about $20 a vial. They also like the high it gives them — what most recreational users strive for is the "K-hole," where they become disassociated from everything around them. They say they feel like they're floating above their bodies. And the high lasts for about 45 minutes — easy to pop on a lunch break.
But it can also have serious side effects, and it's easy to overdo the dosage.
"We get a number of calls from physicians whose patients have had an adverse reaction to ketamine," says Dr. Margaret Thompson, medical director of the Ontario Poison Centre.
"In low doses, they feel things have a different touch, soft and fuzzy. They also feel mellow and in touch with their surroundings. The problem is the right dose and the wrong dose are very closely related — only milligrams apart. So it's serious if a parent sees their child unconscious and unrousable, disoriented or appearing drunk. They should call 911 immediately."
Compounding the problem is the fact repeat users need to increase the dosage of ketamine, which raises the chance of negative side effects.
"Your body becomes tolerant to it, so if you want to get the same effect the next time you have to take more," Thompson said. "While few people have died from taking it, a user could die if they stopped breathing from a depressed central nervous system or because they vomited and choked. It has the potential to cause death, severe adverse reactions and some short term psychosis."
Of the few studies that have been conducted on the effects of ketamine, the Hong Kong Medical Journal published a report this past summer showing the drug was linked to severe bladder and kidney damage among 10 adults between the ages of 21 and 30 who had used the drug for four years.
Unlike street drugs such as methamphetamine hydrochloride (popularly known as crystal meth), ketamine can't be made in home labs. Rather, it's being stolen from veterinarian offices and labs. It can also be purchased on the internet from Mexico or Europe.
Police are treating it seriously. While ketamine used to be listed in the Food and Drug Act, the Controlled Drugs and Substances Act now covers it, so even possession of a vial is illegal in Canada.
One Vancouver man found that out several years ago. A court awarded Bradley Weafer, 38, $63,000 after being given an overdose of ketamine in hospital. He described the experience as being akin to being sucked into black tunnels. He told the court he saw his life flash before his eyes, felt being born and placed in his mother's arms.
"It's more commonly used on children who are not as likely to have bad memories from it," Thompson said.
Ketamine was also part of a successful combination of drugs given to a 15-year-old Wisconsin girl who had been bitten by a rabid bat.
And several years ago, a man experiencing severe chronic pain was placed in a drug-induced coma for seven days and given ketamine. Today, he functions with much less pain, although he has experienced some fleeting hallucinations.
Researchers are also in the early stages of testing its use as a fast-acting antidepressant.
They're the best-selling family of drugs of all time, with annual worldwide sales estimated at more than $20 billion. Every year, Canadian doctors write more than 12 million prescriptions for statins, making them the most-prescribed drugs in the country. They're in a class of drugs that has proven very effective at lowering cholesterol levels and reducing the risk of heart attacks.
The possible effectiveness of statins is so great that surprised researchers reported in November 2008 they have stopped a four-year study two years early in order to present their findings as soon as possible on the drugs' benefits to patients.
The study, which followed nearly 18,000 patients from 27 different countries, found the strongest evidence yet that people with high levels of a particular protein are at increased risk of cardiovascular disease. It also found that the risk dropped by nearly half for patients treated with statins.
All the patients had normal levels of cholesterol (LDL-c) and high levels of hs-CRP (high-sensitivity C-reactive protein) — previously suspected, but not confirmed, to be a critical indicator of heart problems — and as such were not receiving any treatment for cardiovascular disease.
But the study participants who received a daily dose of the drug rosuvastin saw their risk of cardiovascular disease drop by 44 per cent, and their risk of death fall by 21 per cent, compared with participants taking placebo over the same period.
Since statins have a cholesterol-lowering effect, they are currently used to prevent cardiovascular disease in patients who are at risk due to high LDL-c levels. But cardiovascular disease is also caused by vascular inflammation, marked by high levels of hs-CRP, the study suggests.
The study implies that statins act on both cholesterol and inflammation, an effect that has long been suspected but not proven.
Statins are the best-selling family of drugs of all time. If you believe the estimate by the Heart and Stroke Foundation of Canada that four out of five adults have at least one factor increasing their risk of heart attack, then the potential market for statins is huge.
And that market could easily continue to grow. Statins are being called the Aspirin of the 21st century and a miracle drug — because they might actually do a lot more than just prevent heart attacks.
Studies have suggested that statins might also slow the progression of Alzheimer's disease and help patients with osteoporosis and multiple sclerosis. And new data raise the possibility that statins might also ward off colon, breast and prostate cancer — and lower one's overall cancer risk.
The human body actually needs some cholesterol to help with the building and maintenance of cells. Good — or HDL cholesterol — helps the body absorb vitamins and nutrients from food. It helps produce the hormones the body needs.
Bad — or LDL cholesterol — sticks to the inside of blood vessels and arteries, narrowing the path through which blood flows and increasing the risk of forming clots. That's what leads to heart disease and strokes. Combined, those two diseases make up the leading cause of death in Canada, killing nearly 80,000 people a year, almost 40 per cent of all deaths in this country. Cholesterol is to blame in many of those cases.
"We've got these ancient bodies with these ancient genes which are all destined to make sure that we've got enough cholesterol to fulfill essential functions," Jenkins told CBC Radio's Quirks and Quarks. "Today, unfortunately, we've taken out all those nice things in the diet that take cholesterol out of the body and have brought in a whole load of very nice refined foods that allow us to sit around, not do too much, and just synthesize cholesterol."
Those refined foods help your body produce the bad kind of cholesterol. That's where statins come in. They work by blocking an enzyme in the liver that is involved in producing cholesterol within liver cells.
"This tricks the liver cells into thinking the cholesterol levels are too low within the cell and the cell puts more receptors onto its surface, which drag the bad LDL cholesterol out of the blood," explains Dr. Rory Collins, professor of epidemiology at Oxford University. "The liver then breaks down that cholesterol and it's excreted into the bile and into the gut."
Collins conducted the biggest study of statins to date, covering 20,000 people over five years. The study — published in November 2001 — suggested that a person who has had high cholesterol for decades could reduce their risk of heart attack or stroke by 25 per cent within just a few years of statin treatment. The study also suggested that the risk would continue to decrease, the longer the treatment continued.
The study was a factor in the British government's decision to make statins available over the counter to almost anyone over age 55. Britain's health secretary said the move would encourage more people to start taking statins, even those with a moderate risk of heart disease.
Collins argues that giving statins to more people — even those at lower risk — will prevent even more heart attacks.
A study published in the New England Journal of Medicine's Oct. 11, 2007 edition backs that up. The study was a 10-year follow-up of the West of Scotland Coronary Prevention Study. It found that people who started on statins in the early part of the original study had a significantly reduced risk of heart attack than those who started statin therapy after the original study was completed.
Other studies have suggested that statins may have promise in treating other conditions. One found that cholesterol promotes the development of Alzheimer's disease in rabbits. The researchers wanted to see if lowering cholesterol levels in people with Alzheimer's might slow down the disease. Patients on statins were tested on their cognitive abilities, their memory and their feelings of depression. The study found that the patients who had taken statins seemed to be in better shape.
Studies have also suggested that statins may show some promise in the treatment of multiple sclerosis. And, at a meeting of the American Society of Clinical Oncology on June 6, 2004, new research was presented suggesting people who took statins for at least five years appeared to cut their risk of colon cancer in half.
If statins do reduce the risk of cancer, scientists say it may have nothing to do with the drug's effects on cholesterol. One theory is that statins fight off the disease by reducing inflammation. Another theory is statins could block the way some cancer-causing genes work.
Researchers say the evidence is still too weak to recommend taking statins for cancer prevention. They say much more study is needed.
But there is a debate over the widespread use of statins. Some argue that the smaller your risk of developing heart disease, the smaller the benefit you'll get from taking statins. And by taking a pill every day, you might be running the risk of having the harm outweigh the benefits.
Although there are relatively few side effects to statins, they can be quite serious. They include a degenerative muscle disease called myopathy, which can be fatal. Bayer pulled its statin — Baycol — off the market in August 2001 because it caused too many cases of myopathy. Baycol was linked to 52 deaths worldwide, including one in Canada.
According to data obtained by the CBC from Health Canada's adverse drug reaction database, more than 1,000 serious side effects related to statins have been reported in the last 15 years.
The most common side effect in people taking statins in muscle pain. About 15 per cent of people on the medication report some kind of muscle pain. But a study published in the Canadian Medical Association Journal found that the problem could be more widespread — and that much of the damage is not being detected.
The study — published in the July 7, 2009 issue of the journal — looked at muscle tissue from people complaining about pain who used statins. A blood test is supposed to show if statins are causing the pain. But the study found muscle damage even when tests on some people came back negative.
Muscle pain normally disappears days after a patient stops using statins. But in some cases, the pain persisted.
One theory is that statins may impair the body's ability to repair muscles. The researchers say more study is needed — but for patients with persistent symptoms of muscle pain, alternative treatment might need to be considered.
While the researchers continue to probe whether statins should be conferred "wonder-drug" status, some doctors are arguing that — wonder drug or not — there's a simple, drug-free way to get cholesterol-lowering benefits similar to what statins bring: watch what you eat and get some exercise.
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www.udg.edu | Main Entry: | unconscionable |
| Part of Speech: | adjective |
| Definition: | immoral, immoderate |
| Synonyms: | amoral, barbarous, conscienceless, criminal, dishonest, excessive, exorbitant, extravagant, extreme, inordinate, knavish, outrageous, preposterous, sneaky, too much*, uncivilized, undue, unethical, unfair, ungodly, unholy, unjust, unprincipled, unreasonable, unscrupulous, wanton, wicked |
| Antonyms: | decent, good, moral, principled |
* = informal/non-formal usage
| Main Entry: | excessive |
| Part of Speech: | adjective |
| Definition: | too much; overdone |
| Synonyms: | boundless, disproportionate, dissipated, dizzying, enormous, exaggerated, exorbitant, extra, extravagant, extreme, immoderate, indulgent, inordinate, intemperate, limitless, more, needless, over, overboard, overkill, overmuch, plethoric, prodigal, profligate, recrementitious, redundant, self-indulgent, sky-high, steep, stiff, stratospheric, super, superabundant, superfluous, supernatural, too many, towering, unbounded, unconscionable , undue, unmeasurable, unreasonable, way out |
| Antonyms: | insufficient, moderate, reasonable, underdone |
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www.lvlawpr.com | Main Entry: | exorbitant |
| Part of Speech: | adjective |
| Definition: | extravagant, excessive |
| Synonyms: | absonant, dear, enormous, exacting, expensive, extortionate, extreme, high, highway robbery, immoderate, inordinate, out of sight, outrageous, over one's head, overboard, overmuch, preposterous, pricey, steep*, stiff*, towering, unconscionable , undue, unreasonable, unwarranted, up to here, wasteful |
| Antonyms: | cheap, inexpensive, low, moderate, reasonable, sensible |
* = informal/non-formal usage
| Main Entry: | extravagant |
| Part of Speech: | adjective |
| Definition: | indulgent, wasteful |
| Synonyms: | absurd, bizarre, costly, crazy, exaggerated, excessive, exorbitant, expensive, extortionate, extreme, fanciful, fancy, fantastic, flamboyant, flashy, foolish, garish, gaudy, grandiose, immoderate, implausible, improvident, imprudent, inordinate, lavish, ludicrous, nonsensical, ornate, ostentatious, outrageous, overpriced, preposterous, pretentious, prodigal, profligate, reckless, ridiculous, showy, silly, spendthrift, steep, unbalanced, unconscionable , unreasonable, unrestrained |
| Antonyms: | close, economical, moderate, provident, reasonable, saving, stingy, thrifty, unpretentious |
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www.katonamir.com | Main Entry: | immoderate |
| Part of Speech: | adjective |
| Definition: | excessive, extreme |
| Synonyms: | dizzying, egregious, enormous, exaggerated, exorbitant, extravagant, inordinate, intemperate, overindulgent, profligate, steep, too much*, too-too, towering, unbalanced, unbridled, uncalled-for, unconscionable , uncontrolled, undue, unjustified, unmeasurable, unreasonable, unrestrained, unwarranted, wanton |
| Antonyms: | calm, justified, mild, moderate, reasonable, restrained |
* = informal/non-formal usage
| Main Entry: | inordinate |
| Part of Speech: | adjective |
| Definition: | excessive, extravagant |
| Synonyms: | disproportionate, dizzying, exorbitant, extortionate, extreme, gratuitous, immoderate, intemperate, irrational, outrageous, overindulgent, overmuch, preposterous, supererogatory, superfluous, surplus, too much, towering, uncalled-for, unconscionable , uncurbed, undue, unmeasurable, unreasonable, unrestrained, untempered, unwarranted, wanton, wasteful |
| Antonyms: | moderate, ok enough, reasonable, warranted |
| Main Entry: | outrageous |
| Part of Speech: | adjective |
| Definition: | beyond reasonable limits |
| Synonyms: | barbarous, crazy*, excessive, exorbitant, extortionate, extravagant, immoderate, inordinate, last straw, offensive, out of bounds, preposterous, scandalous, shocking, steep*, too much*, uncivilized, unconscionable , unreasonable |
| Antonyms: | acceptable, mild, reasonable, sensible |
* = informal/non-formal usage
| Main Entry: | stiff |
| Part of Speech: | adjective |
| Definition: | extreme, severe |
| Synonyms: | austere, brisk, cruel, drastic, exact, excessive, exorbitant, extravagant, great, hard, harsh, heavy, immoderate, inexorable, inordinate, oppressive, pitiless, potent, powerful, rigorous, sharp, steep, strict, stringent, strong, towering, unconscionable , undue, vigorous |
| Antonyms: | calm, moderate, normal |
| Main Entry: | uncivilized |
| Part of Speech: | adjective |
| Definition: | wild, uncultured |
| Synonyms: | barbarian, barbaric, barbarous, boorish, brutish, churlish, coarse, crass, crude, discourteous, disrespectful, gross, ill-bred, impertinent, impolite, loutish, mannerless, outrageous, philistine, primitive, rude, rugged, savage, unconscionable , uncontrolled, uncouth, uncultivated, uneducated, ungodly, unholy, unmannered, unpolished, unrefined, unsophisticated, vulgar, wicked |
| Antonyms: | civilized, cultured, domesticated, polished, refined, sophisticated |
| Main Entry: | undue |
| Part of Speech: | adjective |
| Definition: | excessive, unnecessary |
| Synonyms: | disproportionate, exceeding, exorbitant, extravagant, extreme, forbidden, ill-timed, illegal, immoderate, improper, inappropriate, inapt, indecorous, inept, inordinate, intemperate, needless, overmuch, sinister, too great, too much, unapt, uncalled-for, unconscionable , underhanded, undeserved, unfair, unfitting, unjust, unjustifiable, unjustified, unmeasurable, unreasonable, unseasonable, unseemly, unsuitable, untimely, unwarrantable, unwarranted |
| Notes: | undo means to reverse an action or thing; undue means 'inappropriate' or 'excessive' |
| Antonyms: | moderate, reasonable, sensible |
| Synonyms: | benumbed, blacked out, bombed, cold*, comatose, dead to the world, drowsy, entranced, feeling no pain, flattened, in a trance, inanimate, inert, insensate, insensible, knocked, lethargic, numb, on the canvas, out, out like a light, palsied, paralyzed, passed out, put away, raving, senseless, stunned, stupefied, swooning, torpid, tranced, zonked |
| Antonyms: | awake, aware, conscious |
| Main Entry: | immoderate |
| Part of Speech: | adjective |
| Definition: | excessive, extreme |
| Synonyms: | dizzying, egregious, enormous, exaggerated, exorbitant, extravagant, inordinate, intemperate, overindulgent, profligate, steep, too much*, too-too, towering, unbalanced, unbridled, uncalled-for, unconscionable , uncontrolled, undue, unjustified, unmeasurable, unreasonable, unrestrained, unwarranted, wanton |
| Antonyms: | calm, justified, mild, moderate, reasonable, restrained |
* = informal/non-formal usage
| Main Entry: | inordinate |
| Part of Speech: | adjective |
| Definition: | excessive, extravagant |
| Synonyms: | disproportionate, dizzying, exorbitant, extortionate, extreme, gratuitous, immoderate, intemperate, irrational, outrageous, overindulgent, overmuch, preposterous, supererogatory, superfluous, surplus, too much, towering, uncalled-for, unconscionable , uncurbed, undue, unmeasurable, unreasonable, unrestrained, untempered, unwarranted, wanton, wasteful |
| Antonyms: | moderate, ok enough, reasonable, warranted |
| Main Entry: | outrageous |
| Part of Speech: | adjective |
| Definition: | beyond reasonable limits |
| Synonyms: | barbarous, crazy*, excessive, exorbitant, extortionate, extravagant, immoderate, inordinate, last straw, offensive, out of bounds, preposterous, scandalous, shocking, steep*, too much*, uncivilized, unconscionable , unreasonable |
| Antonyms: | acceptable, mild, reasonable, sensible |
| Main Entry: | unconscionable |
| Part of Speech: | adjective |
| Definition: | immoral, immoderate |
| Synonyms: | amoral, barbarous, conscienceless, criminal, dishonest, excessive, exorbitant, extravagant, extreme, inordinate, knavish, outrageous, preposterous, sneaky, too much*, uncivilized, undue, unethical, unfair, ungodly, unholy, unjust, unprincipled, unreasonable, unscrupulous, wanton, wicked |
| Antonyms: | decent, good, moral, principled |
* = informal/non-formal usage
| Main Entry: | excessive |
| Part of Speech: | adjective |
| Definition: | too much; overdone |
| Synonyms: | boundless, disproportionate, dissipated, dizzying, enormous, exaggerated, exorbitant, extra, extravagant, extreme, immoderate, indulgent, inordinate, intemperate, limitless, more, needless, over, overboard, overkill, overmuch, plethoric, prodigal, profligate, recrementitious, redundant, self-indulgent, sky-high, steep, stiff, stratospheric, super, superabundant, superfluous, supernatural, too many, towering, unbounded, unconscionable , undue, unmeasurable, unreasonable, way out |
| Antonyms: | insufficient, moderate, reasonable, underdone |
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www.lvlawpr.com | Main Entry: | exorbitant |
| Part of Speech: | adjective |
| Definition: | extravagant, excessive |
| Synonyms: | absonant, dear, enormous, exacting, expensive, extortionate, extreme, high, highway robbery, immoderate, inordinate, out of sight, outrageous, over one's head, overboard, overmuch, preposterous, pricey, steep*, stiff*, towering, unconscionable , undue, unreasonable, unwarranted, up to here, wasteful |
| Antonyms: | cheap, inexpensive, low, moderate, reasonable, sensible |
* = informal/non-formal usage
| Main Entry: | extravagant |
| Part of Speech: | adjective |
| Definition: | indulgent, wasteful |
| Synonyms: | absurd, bizarre, costly, crazy, exaggerated, excessive, exorbitant, expensive, extortionate, extreme, fanciful, fancy, fantastic, flamboyant, flashy, foolish, garish, gaudy, grandiose, immoderate, implausible, improvident, imprudent, inordinate, lavish, ludicrous, nonsensical, ornate, ostentatious, outrageous, overpriced, preposterous, pretentious, prodigal, profligate, reckless, ridiculous, showy, silly, spendthrift, steep, unbalanced, unconscionable , unreasonable, unrestrained |
| Antonyms: | close, economical, moderate, provident, reasonable, saving, stingy, thrifty, unpretentious |
If you ask a teenager about 'Special K' these days, don’t expect them to immediately reach for a cereal bowl. That's because it's the nickname of the drug du jour — ketamine.
Although immensely popular with younger people, few parents are savvy about the new recreational drug that's giving teenagers a quick, dramatic high.
Ketamine is used by veterinarians, doctors and dentists as a dissociative anaesthetic and painkiller, but is appearing increasingly on the streets.
"Kids are taking it at clubs, but it's also a date rape drug," Det. Sgt. Howie Page of Toronto police explains. "GHB, the most popular date rape drug, renders the victim unconscious — they don't remember anything. Ketamine puts them in a semi-conscious state, paralyzing them so they can't fight back. Young women who willingly take it are putting themselves in danger."
Wende Wood, a psychiatric pharmacist with the Centre for Addiction and Mental Health, adds, "Parents should be concerned that if their child takes ketamine, they may be putting themselves in a situation where could be raped or harmed. I'd worry also if they were really drawn to it. Why do they need to escape?"
Ketamine's attraction
Ketamine recently hit celebrity news when Pete Doherty, boyfriend of supermodel Kate Moss, pleaded guilty to possessing it. It's being picked up in drug busts across Canada as well — it was one of the drugs seized in a large bust in Winnipeg in early October.Ketamine is also showing up mixed with other drugs, such as ecstasy.
Teenagers have a variety of reasons for using it.
It's cheap — about $20 a vial. They also like the high it gives them — what most recreational users strive for is the "K-hole," where they become disassociated from everything around them. They say they feel like they're floating above their bodies. And the high lasts for about 45 minutes — easy to pop on a lunch break.
But it can also have serious side effects, and it's easy to overdo the dosage.
"We get a number of calls from physicians whose patients have had an adverse reaction to ketamine," says Dr. Margaret Thompson, medical director of the Ontario Poison Centre.
"In low doses, they feel things have a different touch, soft and fuzzy. They also feel mellow and in touch with their surroundings. The problem is the right dose and the wrong dose are very closely related — only milligrams apart. So it's serious if a parent sees their child unconscious and unrousable, disoriented or appearing drunk. They should call 911 immediately."
Wood advises, "If your teen makes the bad decision to use K, try to make sure the 20 other decisions surrounding it are good. Make sure they're with people they know, have a drive home and have a buddy who can help them in a bad situation."What users experience
Understanding what people tend to feel when under the influence of ketamine can play a role in helping to identify habitual users.
"When I snort ketamine I feel numb," said 15-year-old Art (not his real name). "You're outside yourself — it's a total escape for a good 45 minutes. It's like someone took a refractor and split it into two different images — like a cracked mirror on an angle."
The experience can also be scary.
"I've seen stuff that scared the hell out of me," Art remembers. "One time I was on a bed and saw myself being pulled down through the floor as if I was being pulled into hell. Sometimes I see experiences that seem like they've happened to me, but I don't think they have."
Some users complain of what they call K-pains. "I don't like the feeling after," Art said. "Sometimes my whole body hurts. Urinating after has hurt me quite a bit."
"It feels like a complete weird world of new and interesting things," said 16-year-old Phillip (not his real name).
"Physical touch is exaggerated. When I hallucinate it's in green and purple. But it's usually only in the dark or when it's very light. I have insane dreams on it. Sometimes I forget how to speak or move my lips; however, I also become very aware of my surroundings. Sometimes I feel frail or strong, very lonely or very happy."
"The taste is nice, there’s no comedown and it's short acting," Phillip adds. "It's also unnoticeable. It's very cozy and it also gives a major ego swing upward — so you feel very cocky. You can get ketamine from anyone. It's the most popular teenage drug, I would say."
However, Phillip complains about K-pains as well. "I hate those, but they only happen if you do it a lot," he said.
Compounding the problem is the fact repeat users need to increase the dosage of ketamine, which raises the chance of negative side effects.
"Your body becomes tolerant to it, so if you want to get the same effect the next time you have to take more," Thompson said. "While few people have died from taking it, a user could die if they stopped breathing from a depressed central nervous system or because they vomited and choked. It has the potential to cause death, severe adverse reactions and some short term psychosis."
Long-term effects
As far as long term effects, ketamine simply hasn’t been used long enough on the street for that to be known. Teenagers are the guinea pigs.Of the few studies that have been conducted on the effects of ketamine, the Hong Kong Medical Journal published a report this past summer showing the drug was linked to severe bladder and kidney damage among 10 adults between the ages of 21 and 30 who had used the drug for four years.
Unlike street drugs such as methamphetamine hydrochloride (popularly known as crystal meth), ketamine can't be made in home labs. Rather, it's being stolen from veterinarian offices and labs. It can also be purchased on the internet from Mexico or Europe.
Police are treating it seriously. While ketamine used to be listed in the Food and Drug Act, the Controlled Drugs and Substances Act now covers it, so even possession of a vial is illegal in Canada.
Legitimate uses
Ketamine isn't without its positive applications. "It's used in emergency departments as a painkiller, although it's rarely used in adults as a sedative or analgesic because it’s associated with bad trips," Thompson said.One Vancouver man found that out several years ago. A court awarded Bradley Weafer, 38, $63,000 after being given an overdose of ketamine in hospital. He described the experience as being akin to being sucked into black tunnels. He told the court he saw his life flash before his eyes, felt being born and placed in his mother's arms.
"It's more commonly used on children who are not as likely to have bad memories from it," Thompson said.
Ketamine was also part of a successful combination of drugs given to a 15-year-old Wisconsin girl who had been bitten by a rabid bat.
And several years ago, a man experiencing severe chronic pain was placed in a drug-induced coma for seven days and given ketamine. Today, he functions with much less pain, although he has experienced some fleeting hallucinations.
Researchers are also in the early stages of testing its use as a fast-acting antidepressant.
They're the best-selling family of drugs of all time, with annual worldwide sales estimated at more than $20 billion. Every year, Canadian doctors write more than 12 million prescriptions for statins, making them the most-prescribed drugs in the country. They're in a class of drugs that has proven very effective at lowering cholesterol levels and reducing the risk of heart attacks.
The possible effectiveness of statins is so great that surprised researchers reported in November 2008 they have stopped a four-year study two years early in order to present their findings as soon as possible on the drugs' benefits to patients.
The study, which followed nearly 18,000 patients from 27 different countries, found the strongest evidence yet that people with high levels of a particular protein are at increased risk of cardiovascular disease. It also found that the risk dropped by nearly half for patients treated with statins.
All the patients had normal levels of cholesterol (LDL-c) and high levels of hs-CRP (high-sensitivity C-reactive protein) — previously suspected, but not confirmed, to be a critical indicator of heart problems — and as such were not receiving any treatment for cardiovascular disease.
But the study participants who received a daily dose of the drug rosuvastin saw their risk of cardiovascular disease drop by 44 per cent, and their risk of death fall by 21 per cent, compared with participants taking placebo over the same period.
Since statins have a cholesterol-lowering effect, they are currently used to prevent cardiovascular disease in patients who are at risk due to high LDL-c levels. But cardiovascular disease is also caused by vascular inflammation, marked by high levels of hs-CRP, the study suggests.
The study implies that statins act on both cholesterol and inflammation, an effect that has long been suspected but not proven.
Statins are the best-selling family of drugs of all time. If you believe the estimate by the Heart and Stroke Foundation of Canada that four out of five adults have at least one factor increasing their risk of heart attack, then the potential market for statins is huge.And that market could easily continue to grow. Statins are being called the Aspirin of the 21st century and a miracle drug — because they might actually do a lot more than just prevent heart attacks.
Studies have suggested that statins might also slow the progression of Alzheimer's disease and help patients with osteoporosis and multiple sclerosis. And new data raise the possibility that statins might also ward off colon, breast and prostate cancer — and lower one's overall cancer risk.
The human body actually needs some cholesterol to help with the building and maintenance of cells. Good — or HDL cholesterol — helps the body absorb vitamins and nutrients from food. It helps produce the hormones the body needs.
Bad — or LDL cholesterol — sticks to the inside of blood vessels and arteries, narrowing the path through which blood flows and increasing the risk of forming clots. That's what leads to heart disease and strokes. Combined, those two diseases make up the leading cause of death in Canada, killing nearly 80,000 people a year, almost 40 per cent of all deaths in this country. Cholesterol is to blame in many of those cases.
Cholesterol had its uses
At one time, millennia ago, it may have been important for the human body to be able to produce cholesterol — because early humans may have gone long periods between meals, which meant they couldn't count on getting enough cholesterol. But Dr. David Jenkins — a Canada Research Chair in nutrition, and a professor of medicine at the University of Toronto — says that's not the case for the modern couch potato."We've got these ancient bodies with these ancient genes which are all destined to make sure that we've got enough cholesterol to fulfill essential functions," Jenkins told CBC Radio's Quirks and Quarks. "Today, unfortunately, we've taken out all those nice things in the diet that take cholesterol out of the body and have brought in a whole load of very nice refined foods that allow us to sit around, not do too much, and just synthesize cholesterol."
Those refined foods help your body produce the bad kind of cholesterol. That's where statins come in. They work by blocking an enzyme in the liver that is involved in producing cholesterol within liver cells.
"This tricks the liver cells into thinking the cholesterol levels are too low within the cell and the cell puts more receptors onto its surface, which drag the bad LDL cholesterol out of the blood," explains Dr. Rory Collins, professor of epidemiology at Oxford University. "The liver then breaks down that cholesterol and it's excreted into the bile and into the gut."
Collins conducted the biggest study of statins to date, covering 20,000 people over five years. The study — published in November 2001 — suggested that a person who has had high cholesterol for decades could reduce their risk of heart attack or stroke by 25 per cent within just a few years of statin treatment. The study also suggested that the risk would continue to decrease, the longer the treatment continued.
The study was a factor in the British government's decision to make statins available over the counter to almost anyone over age 55. Britain's health secretary said the move would encourage more people to start taking statins, even those with a moderate risk of heart disease.
Collins argues that giving statins to more people — even those at lower risk — will prevent even more heart attacks.
A study published in the New England Journal of Medicine's Oct. 11, 2007 edition backs that up. The study was a 10-year follow-up of the West of Scotland Coronary Prevention Study. It found that people who started on statins in the early part of the original study had a significantly reduced risk of heart attack than those who started statin therapy after the original study was completed.
Other studies have suggested that statins may have promise in treating other conditions. One found that cholesterol promotes the development of Alzheimer's disease in rabbits. The researchers wanted to see if lowering cholesterol levels in people with Alzheimer's might slow down the disease. Patients on statins were tested on their cognitive abilities, their memory and their feelings of depression. The study found that the patients who had taken statins seemed to be in better shape.
Studies have also suggested that statins may show some promise in the treatment of multiple sclerosis. And, at a meeting of the American Society of Clinical Oncology on June 6, 2004, new research was presented suggesting people who took statins for at least five years appeared to cut their risk of colon cancer in half.
If statins do reduce the risk of cancer, scientists say it may have nothing to do with the drug's effects on cholesterol. One theory is that statins fight off the disease by reducing inflammation. Another theory is statins could block the way some cancer-causing genes work.
Researchers say the evidence is still too weak to recommend taking statins for cancer prevention. They say much more study is needed.
But there is a debate over the widespread use of statins. Some argue that the smaller your risk of developing heart disease, the smaller the benefit you'll get from taking statins. And by taking a pill every day, you might be running the risk of having the harm outweigh the benefits.
Although there are relatively few side effects to statins, they can be quite serious. They include a degenerative muscle disease called myopathy, which can be fatal. Bayer pulled its statin — Baycol — off the market in August 2001 because it caused too many cases of myopathy. Baycol was linked to 52 deaths worldwide, including one in Canada.
According to data obtained by the CBC from Health Canada's adverse drug reaction database, more than 1,000 serious side effects related to statins have been reported in the last 15 years.
The most common side effect in people taking statins in muscle pain. About 15 per cent of people on the medication report some kind of muscle pain. But a study published in the Canadian Medical Association Journal found that the problem could be more widespread — and that much of the damage is not being detected.
The study — published in the July 7, 2009 issue of the journal — looked at muscle tissue from people complaining about pain who used statins. A blood test is supposed to show if statins are causing the pain. But the study found muscle damage even when tests on some people came back negative.
Muscle pain normally disappears days after a patient stops using statins. But in some cases, the pain persisted.
One theory is that statins may impair the body's ability to repair muscles. The researchers say more study is needed — but for patients with persistent symptoms of muscle pain, alternative treatment might need to be considered.
While the researchers continue to probe whether statins should be conferred "wonder-drug" status, some doctors are arguing that — wonder drug or not — there's a simple, drug-free way to get cholesterol-lowering benefits similar to what statins bring: watch what you eat and get some exercise.
